IgG Avidity Test for the Diagnosis of Acute Toxoplasma gondii Infection in Early

Authors

  • Abolfazl Porhasan Infectious Disease and Tropical Research Center of Tabriz University of Medical Sciences, Tabriz, Iran
  • Behroz Nagili Infectious Disease and Tropical Research Center of Tabriz University of Medical Sciences, Tabriz, Iran
  • Gafar Olade Gaffari Infectious Disease and Tropical Research Center of Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammad Hashemi Infectious Disease and Tropical Research Center of Tabriz University of Medical Sciences, Tabriz, Iran
  • Mojtaba Varshoghi Infectious Disease and Tropical Research Center of Tabriz University of Medical Sciences, Tabriz, Iran
  • Omid Ali Gardashkhani Infectious Disease and Tropical Research Center of Tabriz University of Medical Sciences, Tabriz, Iran
  • Parviz Salehi Infectious Disease and Tropical Research Center of Tabriz University of Medical Sciences, Tabriz, Iran
  • Shabnam Pour Abolghasem Women's Reproductive Health Research Center
  • Zohre Babaloo Department of Immunology, Medicine Faculty and Drug Applied Research Center
Abstract:

Background: Toxoplasmosis is well known as an important infection in pregnant women. Although many serologic methods are available, diagnosis of early Toxoplasmosis may be extremely difficult. Objective: To detect the Toxoplasma IgG antibodies developed at the early stage of infection in pregnant women. Methods: 225 pregnant women, who were in the 2nd to 4th month of their pregnancy, enrolled in this study. Anti-toxoplasma IgG, IgM and IgG avidity were evaluated by ELISA method. Results: The patients were categorized into three groups as follows: Group A, 124 cases; IgG+, IgM+, 55.1%; group B, 99 cases; IgG+, IgM-, 44%; and group C, 2 cases; IgG -, IgM +, 0.9%. Fifty five percent of the pregnant women had positive IgG and IgM among which 7.1% had low avidity which revealed an active infection in the pregnant women. In the current study, 44% of pregnant women had positive IgG and negative IgM, all of which had high avidity, which is an indication that in our population the level of toxoplasmosis infection is high and most women have had contacts with this parasite before pregnancy. Conclusion: In this study, the low avidity test was 7.1% showing that the occurrence of toxoplasmosis infection is still a serious issue. Observation of 45.8% high avidity among group A suggests that either IgM has a high half-life or there is a false positive IgM as a result of rheumatologic disorders. Therefore, avidity test is important in predicting maternal toxoplasmosis which is of value in disease treatment.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

igg avidity test for the diagnosis of acute toxoplasma gondii infection in early

background: toxoplasmosis is well known as an important infection in pregnant women. although many serologic methods are available, diagnosis of early toxoplasmosis may be extremely difficult. objective: to detect the toxoplasma igg antibodies developed at the early stage of infection in pregnant women. methods: 225 pregnant women, who were in the 2nd to 4th month of their pregnancy, enrolled i...

full text

IgG avidity test for the diagnosis of acute Toxoplasma gondii infection in early pregnancy.

BACKGROUND Toxoplasmosis is well known as an important infection in pregnant women. Although many serologic methods are available, diagnosis of early Toxoplasmosis may be extremely difficult. OBJECTIVE To detect the Toxoplasma IgG antibodies developed at the early stage of infection in pregnant women. METHODS 225 pregnant women, who were in the 2nd to 4th month of their pregnancy, enrolled ...

full text

Detection of acute Toxoplasma gondii infection in early pregnancy by IgG avidity and PCR analysis.

Acute Toxoplasma gondii infection in early pregnancy carries the risk of transmitting the infection to the fetus with serious sequelae. However, serological testing for IgG/IgM anti-Toxoplasma antibodies may fail to differentiate between a recent and past infection. Two hundred and twenty-four Kuwaiti women in their first trimester were screened for IgG/IgM antibodies by the Vitek Immuno Diagno...

full text

modification and evaluation of avidity igg testing for differentiating of toxoplasma gondii infection in early stage of pregnancy

objective: toxoplasma gondii infection, an intracellular parasite, is often asymptomatic or is caused by different clinical diseases without being detected. evaluation of igg, iga, and igm in order to diagnose the pending toxoplasmosis may confront some problems. several researches has showned that toxo igg avidity can be useful in the recent active toxoplasmosis. in current study, modification...

full text

Modification and Evaluation of Avidity IgG Testing for Differentiating of Toxoplasma gondii Infection in Early Stage of Pregnancy

OBJECTIVE Toxoplasma gondii infection, an intracellular parasite, is often asymptomatic or is caused by different clinical diseases without being detected. Evaluation of IgG, IgA, and IgM in order to diagnose the pending Toxoplasmosis may confront some problems. Several researches has showned that Toxo IgG avidity can be useful in the recent active Toxoplasmosis. In current study, modification ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 8  issue 4

pages  251- 255

publication date 2011-12-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023